解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The most common complication after cataract surgery is postoperative capsular opacification, which includes anterior capsular opacification (ACO) and posterior capsular opacification (PCO). Increased adhesion of lens epithelial cells (LECs) to the intraocular lens material surface promotes ACO formation, whereas proli...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.315
更新日期:2017-07-13 00:00:00
abstract::miRNAs are involved in many physiologic and disease processes by virtue of degrading specific mRNAs or inhibiting their translation. miR-148a has been implicated in the control of tumor growth and cholesterol and triglyceride homeostasis using in vitro or in vivo gene expression- and silencing-based approaches. Here m...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.309
更新日期:2017-07-13 00:00:00
abstract::Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.307
更新日期:2017-07-06 00:00:00
abstract::Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage from reactive oxygen species (ROS). However, its function in trophoblasts at the maternal-fetal interface has not been clarified yet. In th...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.301
更新日期:2017-06-29 00:00:00
abstract::The NF-κB family of transcription factors is important for many cellular functions, in particular initiation and propagation of inflammatory and immune responses. However, recent data has suggested that different subunits of the NF-κB family can suppress the inflammatory response. NF-κB1, from the locus nfκb1, can inh...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.233
更新日期:2017-06-15 00:00:00
abstract::Following stroke-induced neuronal damage, quiescent oligodendrocyte precursors (OPCs) are activated to proliferate and later to differentiate to myelin-producing cells. GPR17, a receptor transiently expressed on early OPCs, has emerged as a target to implement stroke repair through stimulation of OPC maturation. Howev...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.256
更新日期:2017-06-08 00:00:00
abstract::Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it may enhance anti-tumor and antiviral effects of CD8 T cells. Here we investigate the mechanisms by which IFNγ mediates CD8 T-cell cytotoxic f...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.67
更新日期:2017-06-01 00:00:00
abstract::Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer's disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.243
更新日期:2017-06-01 00:00:00
abstract::Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cance...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.225
更新日期:2017-06-01 00:00:00
abstract::Transient receptor potential vanilloid 4 (TRPV4) is highly expressed in heart and vessels and can be activated during myocardial ischemia/reperfusion (I/R). Recently, we found that treatment with a selective TRPV4 antagonist HC-067047 significantly reduced infarct size, decreased troponin T levels and improved cardiac...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.227
更新日期:2017-05-25 00:00:00
abstract::This corrects the article DOI: 10.1038/cddis.2017.172. ...
journal_title:Cell death & disease
pub_type: 杂志文章,已发布勘误
doi:10.1038/cddis.2017.246
更新日期:2017-05-25 00:00:00
abstract::Serum deprivation or withdrawal induces apoptosis in endothelial cells, resulting in endothelial cell dysfunction that is associated with cardiovascular disease. However, there is still limited information on the role of miRNA in serum deprivation-induced apoptosis. Here we found that serum deprivation increased caspa...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.219
更新日期:2017-05-18 00:00:00
abstract::Cancer is the second leading cause of death worldwide. Current treatment strategies based on multi-agent chemotherapy and/or radiation regimens have improved overall survival in some cases. However, resistance to apoptosis often develops in cancer cells, and its occurrence is thought to contribute to treatment failure...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.217
更新日期:2017-05-18 00:00:00
abstract::N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial-mesenchymal transition. However, the role of NMI in the regulation of cancer stem cells (CSCs) remains poorly understood. In this stud...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.200
更新日期:2017-05-11 00:00:00
abstract::Thioredoxin-interacting protein (TXNIP) is involved in oxidative stress and apoptosis in diabetic retinopathy. However, the role of TXNIP in the removal of damaged mitochondria (MT) via mitophagy, a process of macroautophagy, remains unexplored. Here we investigate the associated cellular and molecular mechanisms unde...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.190
更新日期:2017-05-11 00:00:00
abstract::Gallbladder cancer (GBC) is one of the most common malignancy of the biliary tract characterized by its high chemoresistant tendency. Although great progresses have been made in recent decades for treating many cancers with anticancer drugs, effective therapeutics methods for anti-GBC are still lacking. Therefore, inv...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.178
更新日期:2017-05-11 00:00:00
abstract::Sepsis is a systemic inflammation caused by infection. The balance between M1-M2 macrophage polarization has an essential role in the pathogenesis of sepsis. However, the exact mechanism underlying macrophage polarization is unclear. We previously showed that levels of malignant fibrous histiocytoma amplified sequence...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.102
更新日期:2017-05-04 00:00:00
abstract::WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family and functions as a scaffold protein during telomerase assembly, Cajal body formation and DNA double strand break repair. We have previously shown that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung ca...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.162
更新日期:2017-04-13 00:00:00
abstract::Many types of tumor cell are devoid of the extracellular matrix proteoglycan osteoglycin (Ogn), but its role in tumor biology is poorly studied. Here we show that RNAi of Ogn attenuates stress-triggered cell death, whereas its overexpression increases cell death. We found that the transcription factor C/EBPβ regulates...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.155
更新日期:2017-04-06 00:00:00
abstract::Spermidine, a natural polyamine presented widely in mammalian cells, has been implicated to extend the lifespan of several model organisms by inducing autophagy. However, the effect of spermidine against neuronal damage has not yet been fully determined. In this study, neuronal cell injury was induced by treating PC12...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.161
更新日期:2017-04-06 00:00:00
abstract::Erwinia asparaginase, a bacteria-derived enzyme drug, has been used in the treatment of various cancers, especially acute lymphoblastic leukemia (ALL). One of the most significant side effects associated with asparaginase administration is immune suppression, which limits its application in clinic. Macrophages are pha...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.144
更新日期:2017-03-30 00:00:00
abstract::Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis. However, the underlying molecular mechanisms of N...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.132
更新日期:2017-03-23 00:00:00
abstract::Triple negative breast cancers (TNBC) are highly aggressive and lack specific targeted therapies. Recent studies have reported high expression of the transcription factor Kaiso in triple negative tumors, and this correlates with their increased aggressiveness. However, little is known about the clinical relevance of K...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.92
更新日期:2017-03-23 00:00:00
abstract::Upregulation of Smad7, an inhibitor of transforming growth factor-β1 (TGF-β1), occurs in sporadic colorectal cancer (CRC) and knockdown of Smad7 inhibits CRC cell growth, a phenomenon that associates with decreased expression of cell division cycle 25 homolog A and arrest of cells in the S phase of the cell cycle. The...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.103
更新日期:2017-03-16 00:00:00
abstract::The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as well as solid tumors, but shows dose-dependent potentially life-threatening toxicities and can induce secondary malignancies. Thus, the clinical utility of CTX wo...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.108
更新日期:2017-03-16 00:00:00
abstract::Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but often acquire oncogenic gain-of-functions (GOFs). GOF manifests itself in accelerated tumor onset, increased metastasis, increased drug r...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.80
更新日期:2017-03-09 00:00:00
abstract::T-cell-mediated immune responses aim to protect mammals against cancers and infections, and are also involved in the pathogenesis of various inflammatory or autoimmune diseases. Cellular uptake and the utilization of nutrients is closely related to the T-cell fate decision and function. Research in this area has yield...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
doi:10.1038/cddis.2016.222
更新日期:2017-03-02 00:00:00
abstract::The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic transcription factor NF-κB. Recently, missense mutations in CARMA2sh have been shown to cause...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.51
更新日期:2017-02-23 00:00:00
abstract::Current practices for the therapy of chondrosarcoma, including wide-margin surgical resection and chemotherapy, are less than satisfactory. Recently, emerging evidence has demonstrated that long non-coding RNAs (lncRNAs) have an essential role in the initiation and progression of tumors. As a typical lncRNA, HOTAIR is...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.31
更新日期:2017-02-09 00:00:00
abstract::Mammalian folliculogenesis is a complex process in which primordial follicles develop into pre-ovulatory follicles, followed by ovulation to release mature oocytes. In this study, we explored the role of miR-144 in ovulation. miR-144 was one of the differentially expressed microRNAs, which showed 5.59-fold changes, in...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.24
更新日期:2017-02-09 00:00:00
abstract::Obesity has been associated with increased incidence and mortality of a wide variety of human cancers including colorectal cancer. However, the molecular mechanism by which adipocytes regulate the metabolism of colon cancer cells remains elusive. In this study, we showed that adipocytes isolated from adipose tissues o...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.21
更新日期:2017-02-02 00:00:00
abstract::Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL). The kinase of RIPK3 phosphorylates MLKL causing MLKL to form a pore-like structure, allowing intracellular contents to release and cell dea...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.20
更新日期:2017-02-02 00:00:00
abstract::Cellular acetylation homeostasis is a kinetic balance precisely controlled by histone acetyl-transferase (HAT) and histone deacetylase (HDAC) activities. The loss of the counterbalancing function of basal HAT activity alters the precious HAT:HDAC balance towards enhanced histone deacetylation, resulting in a loss of a...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.465
更新日期:2017-01-26 00:00:00
abstract::Histological inspection of visually normal tissue adjacent to neoplastic lesions often reveals multiple foci of cellular abnormalities. This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic reactive oxygen speci...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.492
更新日期:2017-01-19 00:00:00
abstract::Japanese encephalitis virus (JEV), which is a causative agent of sporadic encephalitis, harbours itself inside the neural stem/progenitor cells. It is a well-known fact that JEV infects neural stem/progenitor cells and decreases their proliferation capacity. With mass spectrometry-based quantitative proteomic study, i...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.394
更新日期:2017-01-19 00:00:00
abstract::Sponges of the porifera family harbor some of the evolutionary most ancient orthologs of the B-cell lymphoma-2 (Bcl-2) family, a protein family critical to regulation of apoptosis. The genome of the sponge Geodia cydonium contains the putative pro-survival Bcl-2 homolog BHP2, which protects sponge tissue as well as ma...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.469
更新日期:2017-01-12 00:00:00
abstract::The ubiquitin-proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a major role in the pat...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.443
更新日期:2017-01-05 00:00:00
abstract::Tumor metastasis leads to high mortality; therefore, understanding the mechanisms that underlie tumor metastasis is crucial. Generally seen as a secretory protein, osteopontin (OPN) is involved in multifarious pathophysiological events. Here, we present a novel pro-metastatic role of OPN during metastatic colonization...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.422
更新日期:2016-12-29 00:00:00
abstract::Ovarian cancer (OC) is the second leading cause of gynecological cancer death worldwide. Although the list of biomarkers is still growing, molecular mechanisms involved in OC development and progression remain elusive. We recently demonstrated that lower expression of the molecular chaperone TRAP1 in OC patients corre...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.400
更新日期:2016-12-15 00:00:00
abstract::The Notch cascade is a fundamental and highly conserved pathway able to control cell-fate. The Notch pathway arises from the interaction of one of the Notch receptors (Notch1-4) with different types of ligands; in particular, the Notch pathway can be activated canonically (through the ligands Jagged1, Jagged2, DLL1, D...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
doi:10.1038/cddis.2016.408
更新日期:2016-12-08 00:00:00